NAD+ dependent 7ß-hydroxysteroid dehydrogenase

The present invention relates to a NAD+ dependent 7B- hydroxysteroid dehydrogenases and to methods of providing a 7B- hydroxysteroid dehydrogenase with a co-substrate specificity of NAD+ instead of NADP+. The invention further relates to methods for converting cholic acid (CA) and/or chenodeoxycholi...

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Bibliographische Detailangaben
Hauptverfasser:	ISABELLA WILHELMINA CHRISTINA EVERDINA ARENDS, FABIO TONIN
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a NAD+ dependent 7B- hydroxysteroid dehydrogenases and to methods of providing a 7B- hydroxysteroid dehydrogenase with a co-substrate specificity of NAD+ instead of NADP+. The invention further relates to methods for converting cholic acid (CA) and/or chenodeoxycholic acid (CDCA) into ursocholic acid (UCA) and/or ursodeoxycholic acid (UDCA) respectively, and more specifically methods for converting 7-oxo-deoxycholic acid (7-oxo-DCA) and/or 7-oxo-lithocholic acid (7-oxo LCA) into ursocholic acid (UCA) and/or ursodeoxycholic acid (UDCA) respectively, by using an NAD+ dependent 7B- hydroxysteroid dehydrogenase.