LIGHT DETECTION DEVICES WITH PROTECTIVE LINER AND METHODS OF MANUFACTURING SAME

Light detection devices and corresponding methods are provided. The devices may include a reaction structure for containing a reaction solution and at least one reaction site that generates light emissions in response to incident excitation light after treatment With the reaction solution. The devices may include a device base positioned beneath the reaction structure that includes a plurality of light sensors and device circuitry electrically coupled to the light sensors. The device base may also include a plurality of light guides With input regions that receive the excitation light and the light emissions. The light guides may include at least one filter material that filters the excitation light and permits the light emissions to pass to at least one corresponding light sensor. The device base may also include a protection layer positioned between each light guide and the device circuitry that prevents the reaction solution from interacting With the circuitry.