PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER

The present invention provides MDM2 inhibitor compounds of Formula (I), wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibit...

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Hauptverfasser:	WANG, XIAODONG, DUQUETTE, JASON, DEIGNAN, JEFFREY, FISHER, BENJAMIN, MCGEE, LAWRENCE, EKSTEROWICZ, JOHN, MCINTOSH, JOEL, ZHU, JIANG, BECK, HILARY PLAKE, FU, JIASHENG, GUSTIN, DARIN JAMES, LI, ZHIHONG, JOHNSON, MICHAEL, WANG, YINGCHAI, MCMINN, DUSTIN, XIAOQI CHEN, LAI, SUJEN, REW, YOSUP, HUANG, XIN, SUN, DAQING, HEATH, JULIE ANNE, MEDINA, JULIO CESAR, BARTBERGER, MICHAEL DAVID, GONZALEZ LOPEZ DE TURISO, FELIX, LIU, JIWEN, CONNORS, RICHARD VICTOR, KOPECKY, DAVID JOHN, MA, ZHIHUA, FU, ZICE, MIHALIC, JEFFREY THOMAS, YAN, XUELEI, FOX, BRIAN MATTHEW, LOW, JONATHAN DANTE, JIAO, XIANYUN, KAYSER, FRANK, GONZALES BUENROSTRO, ANA, GRIBBLE, JR., MICHAEL WILLIAM, OLSON, STEVEN HOWARD, ROVETO, PHILIP MARLEY, LUCAS, BRIAN STUART, YU, MING, LI, YIHONG
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides MDM2 inhibitor compounds of Formula (I), wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.