ACTIVATABLE ANTI-CTLA-4 ANTIBODIES AND USES THEREOF

Provided herein are activatable anti-human CTLA-4 antibodies comprising a heavy chain comprising a VH domain and a light chain comprising a masking moiety (MM), a cleavable moiety (CM), and a VL domain. Such activatable anti- human CTLA-4 antibodies have CTLA-4 binding activity in the tumor microenv...

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Bibliographische Detailangaben
Hauptverfasser: WEST, James William, DESHPANDE, Shrikant, ENGELHARDT, John J, TIPTON, Kimberly Ann
Format: Patent
Sprache:eng
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Zusammenfassung:Provided herein are activatable anti-human CTLA-4 antibodies comprising a heavy chain comprising a VH domain and a light chain comprising a masking moiety (MM), a cleavable moiety (CM), and a VL domain. Such activatable anti- human CTLA-4 antibodies have CTLA-4 binding activity in the tumor microenvironment, where the masking moiety is removed by proteolytic cleavage of the cleavable moiety by tumor-specific proteases, but exhibit greatly reduced binding to CTLA-4 outside the tumor. In this way, the activatable anti-human CTLA-4 antibodies of the present invention retain anti-tumor activity while reducing the side effects associated with anti-CTLA-4 activity outside the tumor.