HIGH-AFFINITY AND AGGREGATIVELY STABLE ANTIBODIES ON THE BASIS OF VARIABLE DOMAINS VL AND A DERIVATIVE VHH

HIGH-AFFINITY AND AGGREGATIVELY STABLE ANTIBODIES ON THE BASIS OF VARIABLE DOMAINS VL AND A DERIVATIVE VHH

The monoclonal IgG-type antibodies comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL are offered. The said antibodies can comprise amino acid substitutes at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies...

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Hauptverfasser: SOLOVIEV, Valeriy Vladimirovich, CHERNYH, Yulia Sergeevna, MOROZOV, Dmitriy Valentinovich, Sofronova, Ekaterina Vladimirovna, GONCHAROVA, Olga Vladimirovna, CHERNOVSKAYA, Tatyana Veniaminovna, ULITIN, Andrey Borisovich, IVANOV, Roman Alexeevich, EVDOKIMOV, Stanislav Rudolfovich, Nemankin Timothy Aleksandrovich, Ustyugov, Yakov Yurevich, KORZHAVIN, Dmitriy Valerievich, Ekimova, Victoria Mikhailovna
Format: Patent
Sprache:eng
Schlagworte:
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BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
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VINEGAR
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Beschreibung
Zusammenfassung:The monoclonal IgG-type antibodies comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL are offered. The said antibodies can comprise amino acid substitutes at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.