1, 2, 4-TRIAZOLO [4,3-A] PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

1, 2, 4-TRIAZOLO [4,3-A] PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

The present invention relates to novel 1 ,2.4-triazolo[4,3-a] pyridine compounds of Formula (I) as positive allosteric modulators (PAMs) of the metabotropic glutamate receptor subtype 2 ("mGiuR2"). The invention is also directed to pharmaceutical compositions comprising such compounds, to...

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Bibliographische Detailangaben
Hauptverfasser: TRABANCO-SUAREZ, ANDRES, AVELINO, LAVREYSEN, HILDE, CEUSTERS, MARC, CID-NU?EZ, JOSE, MARIA
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to novel 1 ,2.4-triazolo[4,3-a] pyridine compounds of Formula (I) as positive allosteric modulators (PAMs) of the metabotropic glutamate receptor subtype 2 ("mGiuR2"). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of mGluR2 subtype disorders.