ATTENUATED RECOMBINANT ALPHAVIRUSES INCAPABLE OF REPLICATING IN MOSQUITOES AND USES THEREOF
The present invention discloses an attenuated recombinant alphavirus that is incapable of replicating in mosquito cells and of tra.,smission by mosquito vectors. These attenuated alphavirus may include but is not limited to Western Equine Encephalitis virus, Eastern equine encephalitis virus, Venezu...
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| Sprache: | eng |
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| Zusammenfassung: | The present invention discloses an attenuated recombinant alphavirus that is incapable of replicating in mosquito cells and of tra.,smission by mosquito vectors. These attenuated alphavirus may include but is not limited to Western Equine Encephalitis virus, Eastern equine encephalitis virus, Venezuelan equine encephalitis virus or Chikungunya virus. The present invention also discloses the method of generating such alphaviruses and thefr use as immunogenic compositions. |
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