BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS

BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS

This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using an...

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Bibliographische Detailangaben
Hauptverfasser: DU, JINFA, CHIN, GREGORY, ELBEL, KRISTYNA, JIANG, ROBERT H, AKTOUDIANAKIS, EVANGELOS, MARTINEZ, RUBEN, SHEVICK, SOPHIE, CORKEY, BRITTON KENNETH, MISH, MICHAEL, METOBO, SAMUEL E, KOBAYASHI, TETSUYA, YANG, HAI, ZABLOCKI, JEFF, SPERANDIO, DAVID
Format: Patent
Sprache:eng
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Zusammenfassung:This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, and X are described herein.