STABLE CRYSTAL FORM OF TIPIRACIL HYDROCHLORIDE AND CRYSTALLIZATION METHOD FOR THE SAME

STABLE CRYSTAL FORM OF TIPIRACIL HYDROCHLORIDE AND CRYSTALLIZATION METHOD FOR THE SAME

An objective of the present invention is to obtain a stable crystal form of 5-chloro-6-(2-iminopyrrolidin-l-yl)methyl-2,4(1H,3H)-pyri midinedione hydrochloride. The present invention provides a crystal of 5-chloro-6-(2-iminopyrrolidin-l-yl)methyl-2,4(1H,3H)-pyri midinedione hydrochloride exhibiting...

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Bibliographische Detailangaben
Hauptverfasser: KAZUNO, HIDEKI, MUTSUMI, TOMONOBU
Format: Patent
Sprache:eng
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Zusammenfassung:An objective of the present invention is to obtain a stable crystal form of 5-chloro-6-(2-iminopyrrolidin-l-yl)methyl-2,4(1H,3H)-pyri midinedione hydrochloride. The present invention provides a crystal of 5-chloro-6-(2-iminopyrrolidin-l-yl)methyl-2,4(1H,3H)-pyri midinedione hydrochloride exhibiting characteristic peaks at angles of 11.6?, 17.2?, 17.8?, 23.3?, 27.1?, and 29.3? as a diffraction angle (20 ? 0.1?) in powder X-ray diffraction.