COMPOUNDS AND THEIR USE

COMPOUNDS AND THEIR USE

Described herein are compounds and their use in the treatment of infections. The compound of formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, solvates, pharmaceutically acceptable salts and pharmaceutical compositions described herein are also useful as P- lactam...

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Bibliographische Detailangaben
Hauptverfasser: APPU, ARAVIND, UDAYAMPALAYAM PALANISAMY, SENTHILKUMAR, NARAYANAN, SHRIDHAR, MANICKAM, SENTHILNATHAN, BALASUBRAMANIAM, GOPALAN, PERIASAMY, HARIHARAN, PAUL SATYASEELA, MANEESH
Format: Patent
Sprache:eng
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Zusammenfassung:Described herein are compounds and their use in the treatment of infections. The compound of formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, solvates, pharmaceutically acceptable salts and pharmaceutical compositions described herein are also useful as P- lactamase inhibitors, which restore or enhance the antibiotic spectrum of a suitable antibiotic agent. The compounds of formula (I) act as inhibitors of f3- lactamases. These compounds restore/potentiate the activities of f3-lactam antibiotics against carbapenemases. These compounds find use in diagnostic method for detecting P-lactamases. [Fig. 1]