REDUCED BY-PRODUCT ACCUMULATION FOR IMPROVED PRODUCTION OF ISOBUTANOL

THE PRESENT INVENTION RELATES TO RECOMBINANT MICROORGANISMS COMPRISING BIOSYNTHETIC PATHWAYS AND METHODS OF USING SAID RECOMBINANT MICROORGANISMS TO PRODUCE VARIOUS BENEFICIAL METABOLITES. IN VARIOUS ASPECTS OF THE INVENTION, THE RECOMBINANT MICROORGANISMS MAY FURTHER COMPRISE ONE OR MORE MODIFICATI...

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Hauptverfasser:	URANO,JUN, PETERS,MATTHEW, JANCAUSKAS,JUSTAS, KELLY,JULIE, DUNDON,CATHERINE ASLESON, BERRY,RUTH, EVANS,KENT, DEY,MELISSA, BASTIAN,SABINE, ARNOLD,FRANCES, HAWKINS,ANDREW, LIES,DOUG, BUELTER,THOMAS, ARISTIDOU,ARISTOS, MEINHOLD,PETER, PORTER-SCHEINMAN,STEPHANIE
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Zusammenfassung:	THE PRESENT INVENTION RELATES TO RECOMBINANT MICROORGANISMS COMPRISING BIOSYNTHETIC PATHWAYS AND METHODS OF USING SAID RECOMBINANT MICROORGANISMS TO PRODUCE VARIOUS BENEFICIAL METABOLITES. IN VARIOUS ASPECTS OF THE INVENTION, THE RECOMBINANT MICROORGANISMS MAY FURTHER COMPRISE ONE OR MORE MODIFICATIONS RESULTING IN THE REDUCTION OR ELIMINATION OF 3 KETO-ACID (E.G., ACETOLACTATE AND 2-ACETO-2-HYDROXYBUTYRATE) AND/OR ALDEHYDE-DERIVED BY PRODUCTS. IN VARIOUS EMBODIMENTS DESCRIBED HEREIN, THE RECOMBINANT MICROORGANISMS MAY BE MICROORGANISMS OF THE SACCHAROMYCES CLADE, CRABTREE-NEGATIVE YEAST MICROORGANISMS, CRABTREE-POSITIVE YEAST MICROORGANISMS, POST-WGD (WHOLE GENOME DUPLICATION) YEAST MICROORGANISMS, PRE-WGD (WHOLE GENOME DUPLICATION) YEAST MICROORGANISMS, AND NON-FERMENTING YEAST MICROORGANISMS.