MICRORNA (MIRNA) AND DOWNSTREAM TARGETS FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES

THE PRESENT INVENTION RELATES TO A PROMOTER REGION OF A MICRORNA, THE USE OF A MICRORNA, IN PARTICULAR MIR-21, AND RELATED ELEMENTS FOR THE DIAGNOSIS AND FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT AND/OR PREVENTION OF FIBROSIS AND/OR FIBROSIS RELATED DISEASES. ADDITIONALLY, THE INVENTION...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	THUM, THOMAS, GROSS, CARINA, BAUERSACHS, JOHANN, ENGELHARDT, STEFAN
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	THE PRESENT INVENTION RELATES TO A PROMOTER REGION OF A MICRORNA, THE USE OF A MICRORNA, IN PARTICULAR MIR-21, AND RELATED ELEMENTS FOR THE DIAGNOSIS AND FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT AND/OR PREVENTION OF FIBROSIS AND/OR FIBROSIS RELATED DISEASES. ADDITIONALLY, THE INVENTION CONCERNS ANTISENSE OLIGONUCLEOTIDES AGAINST TARGETS OF MIR-21. A CELL DEFICIENT FOR MIR-21, THE PROMOTER REGION AND TARGETS OF MIR-21 AND A KNOCK-OUT ORGANISM THEREOF ARE ALSO ENCOMPASSED. FINALLY, THE INVENTION IS DIRECTED TO A METHOD FOR DIAGNOSING FIBROSIS AND/OR FIBROSIS RELATED DISEASES AND TO A METHOD FOR SCREENING A PHARMACEUTICALLY ACTIVE COMPOUND FOR THE TREATMENT OF FIBROSIS AND/OR FIBROSIS RELATED DISEASES. THE PRESENT INVENTION FURTHER RELATES TO COMPOSITIONS FOR USE IN THE TREATMENT, AMELIORATION, AND/OR PREVENTION OF FIBROSIS. IN CERTAIN EMBODIMENTS, THE COMPOSITIONS MODULATE THE ACTIVITY OF A MIRNA FOR THE TREATMENT, AMELIORATION, AND/OR PREVENTION OF FIBROSIS. IN CERTAIN EMBODIMENTS, THE COMPOSITIONS INHIBIT THE ACTIVITY OF MIR-21 FOR THE TREATMENT, AMELIORATION, AND/OR PREVENTION OF FIBROSIS. (FIGURE 1A)