ANTI-CANCER ACTIVITY OF CYTOTOXIC POLYPEPTIDES FROM MALAYSIAN ISOLATES OF BACILLUS THURINGIENSIS

THE PRESENT INVENTION RELATES TO PARASPORAL INCLUSIONS KNOWN AS 8-ENDOTOXIN PRODUCED BY BACILLUS THURINGIENSIS AND WHICH HAS CYTOTOXIC ACTIVITY AGAINST CANCER CELLS. MORE PARTICULARLY, THE PRESENT INVENTION RELATES TO A NON-HAEMOLYTIC BACILLUS THURINGIENSIS PARASPORAL INCLUSIONS WHICH CAN PREFERENTI...

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Hauptverfasser:	SELEENA POORANI BENJAMIN, VISHNA DEVI A/P V NADARAJAH, LEE HAN LIM
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES
Online-Zugang:	Volltext bestellen
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Zusammenfassung:	THE PRESENT INVENTION RELATES TO PARASPORAL INCLUSIONS KNOWN AS 8-ENDOTOXIN PRODUCED BY BACILLUS THURINGIENSIS AND WHICH HAS CYTOTOXIC ACTIVITY AGAINST CANCER CELLS. MORE PARTICULARLY, THE PRESENT INVENTION RELATES TO A NON-HAEMOLYTIC BACILLUS THURINGIENSIS PARASPORAL INCLUSIONS WHICH CAN PREFERENTIALLY KILL LEUKEMIC CELL LINES. THE PARASPORAL INCLUSIONS OF THE PRESENT INVENTION ARE ENCODED BY A FAMILY OF CRY AND CYT GENES AND SHOW SELECTIVE THERAPEUTIC SPECIFICITY FOR CEM-SS CELL LINES AND ARE NON-CYTOTOXIC TO NORMAL T LYMPHOCYTES.