ANTI-IL-12/11-23 ANTIBODIES

ANTI-IL-12/11-23 ANTIBODIES

THE PRESENT INVENTION PROVIDES AN ANTIBODY COMPRISING AN ANTIGEN BINDING DOMAIN WHICH BINDS TO HUMAN IL-12 AND HUMAN IL-23. THE ANTIBODY BINDS HUMAN IL-12P40 EXISTING AS A MONOMER (HUMAN IL-12P40) AND AS A HOMODIMER (HUMAN IL-12P80) AND THE ANTIBODY INHIBITS THE BINDING OF HUMAN IL-12 TO HUMAN IL-12...

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Bibliographische Detailangaben
Hauptverfasser: CLARKE, ADAM, WILLIAM, POW, ANDREW, JAMES, POULTON, LYNN, DOROTHY, DOYLE, ANTHONY GERARD, JENNINGS, PHILIP, ANTHONY, WAI, BERNADETTE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:THE PRESENT INVENTION PROVIDES AN ANTIBODY COMPRISING AN ANTIGEN BINDING DOMAIN WHICH BINDS TO HUMAN IL-12 AND HUMAN IL-23. THE ANTIBODY BINDS HUMAN IL-12P40 EXISTING AS A MONOMER (HUMAN IL-12P40) AND AS A HOMODIMER (HUMAN IL-12P80) AND THE ANTIBODY INHIBITS THE BINDING OF HUMAN IL-12 TO HUMAN IL-12R?2 AND HUMAN IL-23 TO HUMAN IL-23R BUT DOES NOT INHIBIT THE BINDING OF HUMAN IL-12 OR HUMAN IL-23 OR HUMAN IL-12P40 OR HUMAN IL-12P80 TO HUMAN IL-12R?1.