A PHARMACEUTICAL COMPOSITION CONTAINING POLYPEPTIDE FRAGMENTS OF THE SERRALYSINS

THE PRESENT INVENTION IS RELATED TO A COMPOSITION CAPABLE OF INHIBITING THE GROWTH OF TUMORAL CELLS OF DIFFERENT HISTOLOGICAL ORIGINS AND OF ACTIVATED ENDOTHELIAL CELLS. THE COMPONENTS OF SAID COMPOSITIONS ARE POLYPEPTIDE FRAGMENTS OF THE SERRALYSINS, CORRESPONDING TO THE C-TERMINAL FRAGMENT, FROM T...

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Hauptverfasser:	JOSÉ GARCIA SUÁREZ, MÓNICA BEQUET ROMERO, MARÍA DEL CARMEN, ABRAHANTES PÉREZ, JORGE VICTOR GAVILONDO COWLEY, LUIS JAVIER GONZÁLEZ LÓPEZ, JESÚS REYES GONZÁLEZ, RAÚL GÓMEZ RIERA, CARIDAD ANAIS GASMURI GONZÁLEZ, LILA ROSA CASTELLANOS SERRA, MANUEL SELMAN-HOUSEIN SOSA, EDUARDO MARTÍNEZ DÍAZ, GLORIA VÉLIZ RÍOS
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:	THE PRESENT INVENTION IS RELATED TO A COMPOSITION CAPABLE OF INHIBITING THE GROWTH OF TUMORAL CELLS OF DIFFERENT HISTOLOGICAL ORIGINS AND OF ACTIVATED ENDOTHELIAL CELLS. THE COMPONENTS OF SAID COMPOSITIONS ARE POLYPEPTIDE FRAGMENTS OF THE SERRALYSINS, CORRESPONDING TO THE C-TERMINAL FRAGMENT, FROM THE INTERNAL METIONINE TROUGH THE END OF THE MOLECULE, WHICH COULD BE COMBINED AMONG THEM AND OPTIONALLY WITH THE PRODIGIOSINS THAT POTENTIATE THE ANTI-TUMORAL EFFECT OF THE COMPOSITION. THE PRODIGIOSINS IN THE COMPOSITION COULD BE AT A CONCENTRATION OF 0.1 - 100 NM. THE ANTI-PROLIFERATIVE ACTION OF THIS COMPOSITION IS MEDIATED BY APOPTOTIC MECHANISM. IT'S "IN VIVO" ADMINISTRATION HAS ANTI-TUMORAL, ANTIANGIOGENIC AND PROTECTIVE EFFECT AGAINST MALIGNANT TUMORS.