FOUR BRANCHED DENDRIMER-PEG FOR CONJUGATION TO PROTEINS AND PEPTIDES

FOUR BRANCHED DENDRIMER-PEG FOR CONJUGATION TO PROTEINS AND PEPTIDES

A POLYMERIC DENDRIMER-LIKE STRUCTURE WITH FOUR BRANCHES OF MONOMETHOXY- POLYETHYLENE GLYCOL THAT CAN BE REPRESENTED AS: THE CARBOXYLIC GROUP OF THE PREVIOUS STRUCTURE CAN BE FUNCTIONALIZED FOR THE PRODUCTION OF CONJUGATES OF PHARMACEUTICAL INTEREST. THE BINDING OF THIS DENDRIMER-LIKE POLYETHYLENE GL...

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Hauptverfasser: RAMÓN HERNÁNDEZ, JOSÉ, ÁNGEL, CASTRO ODIO, FIDEL RAÚL, FERNÁNDEZ SÁNCHEZ, EDUARDO, PÁEZ MEIRELES, ROLANDO, SÁEZ MARTÍNEZ, VIVIAN, MARÍA
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:A POLYMERIC DENDRIMER-LIKE STRUCTURE WITH FOUR BRANCHES OF MONOMETHOXY- POLYETHYLENE GLYCOL THAT CAN BE REPRESENTED AS: THE CARBOXYLIC GROUP OF THE PREVIOUS STRUCTURE CAN BE FUNCTIONALIZED FOR THE PRODUCTION OF CONJUGATES OF PHARMACEUTICAL INTEREST. THE BINDING OF THIS DENDRIMER-LIKE POLYETHYLENE GLYCOL TO THERAPEUTIC PROTEINS IMPROVES THEIR IN VITRO AND IN VIVO STABILITY.