PURIFICATION PROCESS

PURIFICATION PROCESS FOR THE PREPARATION OF THE ALLYLAMINE PHARMACEUTICAL TERBINAFINE OF FORMULA I IN FREE BASE FORM OR ACID ADDITION SALT FORM, BY DISTILLING CRUDE TERBINAFINE BASE, PREFERABLY BY SHORT PATH DISTILLATION, E.G. AT A TEMPERATURE ABOVE 100°C AND REDUCED PRESSURE, E.G. 0.2 MBAR, AND REC...

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Bibliographische Detailangaben
Hauptverfasser: ULRICH BEUTLER, GERHARD PENN
Format: Patent
Sprache:eng
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Zusammenfassung:PURIFICATION PROCESS FOR THE PREPARATION OF THE ALLYLAMINE PHARMACEUTICAL TERBINAFINE OF FORMULA I IN FREE BASE FORM OR ACID ADDITION SALT FORM, BY DISTILLING CRUDE TERBINAFINE BASE, PREFERABLY BY SHORT PATH DISTILLATION, E.G. AT A TEMPERATURE ABOVE 100°C AND REDUCED PRESSURE, E.G. 0.2 MBAR, AND RECOVERING THE PURIFIED PRODUCT IN FREE BASE OR ACID ADDITION SALT FORM.