INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE

THE PRESENT INVENTION RELATES TO COMPOUNDS THAT INHIBIT SERINE PROTEASE ACTIVITY, PARTICULARLY THE ACTIVITY OF HEPATITIS C VIRUS NS3-NS4A PROTEASE. AS SUCH, THEY ACT BY INTERFERING WITH THE LIFE CYCLE OF THE HEPATITIS C VIRUS AND ARE ALSO USEFUL AS ANTIVIRAL AGENTS. THE INVENTION FURTHER RELATES TO...

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Hauptverfasser:	SHAWN D. BRITT, JOHN J. COURT, ROBERT B. PERNI, JOHN H. VAN DRIE, JANOS PITLIK
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:	THE PRESENT INVENTION RELATES TO COMPOUNDS THAT INHIBIT SERINE PROTEASE ACTIVITY, PARTICULARLY THE ACTIVITY OF HEPATITIS C VIRUS NS3-NS4A PROTEASE. AS SUCH, THEY ACT BY INTERFERING WITH THE LIFE CYCLE OF THE HEPATITIS C VIRUS AND ARE ALSO USEFUL AS ANTIVIRAL AGENTS. THE INVENTION FURTHER RELATES TO COMPOSITIONS COMPRISING THESE COMPOUNDS EITHER FOR EX VIVO USE OR FOR ADMINISTRATION TO A PATIENT SUFFERING FROM HCV INFECTION. THE INVENTION ALSO RELATES TO METHODS OF TREATING AN HCV INFECTION IN A PATIENT BY ADMINISTERING A COMPOSITION COMPRISING A COMPOUND OF THIS INVENTION. THE INVENTION FURTHER RELATES TO PROCESSES FOR PREPARING THESE COMPOUNDS.