PHARMACEUTICAL COMPOSITION CONTAINING GESTAGENS AND/OR ESTROGENS AND 5-METHYL- (6S)- TETRAHYDROFOLATE

28 AHNTRACT THE DRESENT INVENTION RELATES TO A PHARMACEUTICAL 5 COMOCSITION WHICH CCMPRISES PROGESTCAENS, PREFERABLY DROSPIRENONE, ESTROCENS, 1DX-CFERAB-'1V E TN I N Y-', ES T I A D I C I AND 5-METHYL-(6S)-7:CTRAH,,,I@RCFCLE."E, CAN BE EMPLOYED AS CR A 'I CONTRACEPTIVE AND MORECVER PREVENTS DISORDERS CAUSED BY FOLATE DEFICIENCY I N THE CONSUMERS, 4 ') 1 0 DARTICULAR CARDICVASCULAL DISORDERS AND, AFTER CONCEPTION O .1 THE EMHRYO, COPQENITAL MA I F ORMA T IO:@S CAUSED BY FOLATE DEFICIENCY SUCH AS, FOR EXAMPLE, NEURAL TUBE DEFECTS, VENTRICULAR VALVE DEFECTS, URCGENI:AL DEFECTS, AND CLEFT IJP, JAW AND PALATE, 15 WITHOUT MASKING THE SYMPTOMS OF VITAMIN B12 DEFICIENCV, AND A-, THE SAME T4ME EVEN IN THE CASE OF HOMOZYGOUS OR HETEROZYGOUS POLYMOZPHISM OF METHYLENETCZRAHYDROFOLATE XEDUCTA5E FACILITATES UNIMPAIRED UTILIZABILITV OF THE OLATE COMPONENT S-METHYL-(6S)-TET:AHYDRCFCI@TE BY THE 20 BODY AND THUS ITS BIOLOGICAL ACTIVITY FOR PREVENT-I-NA THE ZBOVEMENTIONED CONGENITAL M2LFORMATLONS CAUSED BY FOLATE DEFICIENCY. ---N ADDITION, A PROLONGED PROTECT-4-.E EFFECT I S MA -INTA@ INED AFTER DISCONTINUATION OF THE CONTRACEPTIVE.