METHOD FOR MANUFACTURE OF ESCITALOPRAM

METHOD FOR MANUFACTURE OF ESCITALOPRAM

26 METHOD FOR MANUFACTURE OF ESCITALOPRAM ABSTRACT 5 THIS PATENT DISCLOSES A METHOD FOR RESOLUTION OF 4-[4-(DIMETHYLARNINO)- 1-(4'-FLUOROPHENYL)-L-HYDROXYBUTYL]-3-(HYDROXYMETHYL)-BENZONITFFLE AS A RACEMIC OR NON-RACEMIC ENANTIONIER MIXTURE INTO ITS ISOLATED ENANTIOMERS, SAID METHOD COMPRISING T...

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Bibliographische Detailangaben
Hauptverfasser: ROBERT JAMES DANCER, CARLA DE FAVERI, FLORIAN ANTON MARTIN HUBER
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:26 METHOD FOR MANUFACTURE OF ESCITALOPRAM ABSTRACT 5 THIS PATENT DISCLOSES A METHOD FOR RESOLUTION OF 4-[4-(DIMETHYLARNINO)- 1-(4'-FLUOROPHENYL)-L-HYDROXYBUTYL]-3-(HYDROXYMETHYL)-BENZONITFFLE AS A RACEMIC OR NON-RACEMIC ENANTIONIER MIXTURE INTO ITS ISOLATED ENANTIOMERS, SAID METHOD COMPRISING THE STEP OF FRACTIONALLY CRYSTALLISING 4-[4-(DIMETHYLAMINO)-I-(4'-FLUORO- PHENYL)-L-HYDROXYBUTVL]-3-(HYDROXYMETHYL)-BENZONITRILE AS A SALT WITH THE (+)-(S@S)- 10 OR (-)-(R,R)-ENANTIOMER OF OFF-DI-P-TOLUOYL-TARTARIC ACID IN A SOLVENT SYSTEM COMPRISING I -PROPANOL, ETHANOL OR ACETONITRILE. (NO SUITABLE