2-AMINO-7,8-DIHYDRO-6H-PYRIDO [4,3-D] PYRIMIDIN-5-ONES

2-AMINO-7,8-DIHYDRO-6H-PYRIDO[4,3-D] PYRIMIDIN-5-ONES 5 DISCLOSED ARE 2-AMINO-7,8-DIHYDRO-6H-PYRIDO[4,3-D]PYRIMIDIN-5-ONE COMPOUNDS, THEIR STEREOISOMERS, TAUTOMERS, PHARMACEUTICALLY ACCEPTABLE SALTS, AND PRODRUGS THEREOF; COMPOSITIONS THAT INCLUDE A PHARMACEUTICALLY ACCEPTABLE CARRIEF AND ONE OR MOR...

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Hauptverfasser: BARSANTI, PAUL, A, LIN, XIAODONG, POON, DANIEL, MCBRIDE, CHRISTOPHER, GAO, ZHENHAI, COSTALES, ABRAN, RICO, ALICE, BRAMMEIER, NATHAN, DOLAN, JOHN, GONG, BAOQING, MACHAJEW-SKI, TIMOTHY, D, PICK, TERESA, MENDENHALL, KRIS, ANTONIOS-MCCREA, WILLIAM, WANG, X. MICHAEL, BRINNER, KRISTIN, TULINSKY, JOHN, ZHOU, YASHEEN, MCKENNA, MAUREEN, SHAFER, CYNTHIA, M, GU, DAN, DOUGHAN, BRANDON, M, XIA, YI, RENHOWE, PAUL A, LEVINE, BARRY HASKELL
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Sprache:eng
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Zusammenfassung:2-AMINO-7,8-DIHYDRO-6H-PYRIDO[4,3-D] PYRIMIDIN-5-ONES 5 DISCLOSED ARE 2-AMINO-7,8-DIHYDRO-6H-PYRIDO[4,3-D]PYRIMIDIN-5-ONE COMPOUNDS, THEIR STEREOISOMERS, TAUTOMERS, PHARMACEUTICALLY ACCEPTABLE SALTS, AND PRODRUGS THEREOF; COMPOSITIONS THAT INCLUDE A PHARMACEUTICALLY ACCEPTABLE CARRIEF AND ONE OR MORE OF THE 2-AMINO-7,8-DIHYDRO-6H-PYRIDO[4,3-D]PYRIMIDIN-5- ONE COMPOUNDS, EITHER ALONE OR IN COMBINATION WITH AT LEAST ONE ADDITIONAL 10 THERAPEUTIC AGENT. DISCLOSED ALSO ARE METHODS OF USING THE 2-AMINO-7,8-DIHYDRO- 6H-PYRIDO[4,3-D]PYRIMIDIN-5-ONE COMPOUNDS, EITHER ALONE OR IN COMBINATION WITH AT LEAST ONE ADDITIONAL THERAPEUTIC AGENT, IN THE PROPHYLAXIS OR TREATMENT OF CELLULAR PROLIFERATIVE, VIRAL, AUTOIMMUNE, CARDIOVASCULAR, AND CENTRAL NEVOUS SYSTEM DISEASES