4-PHENYLAMINO-QUINAZOLIN-6-YL-AMIDES

4-PHENYLAMINO-QUINAZOLIN-6-YL-AMIDES

THE INVENTION PROVIDES QUINAZOLINE COMPOUNDS OF THE FORMULA: WHEREIN : R1 IS HALO; R2 IS H OR HALO; R3 IS A) C1-C3 ALKYL, OPTIONALLY SUBSTITUTED BY HALO; OR B) -(CH2)N-MORPHOLINO, -(CH2)N-PIPERIDINE, -(CH2)N-PIPERAZINE, -(CH2)N-PIPERAZINE-N(C1-C3 ALKYL), -(CH2)N-PYRROLIDINE, OR -(CH2)N-IMIDAZOLE; N...

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Bibliographische Detailangaben
Hauptverfasser: HELEN TSENWHEI LEE, KAREN ELAINE SEXTON, KEVIN MATTHEW SCHLOSSER, HAILE TECLE, JESSICA ELIZABETH REED, ROY THOMAS WINTERS, STEPHEN ALAN FAKHOURY
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:THE INVENTION PROVIDES QUINAZOLINE COMPOUNDS OF THE FORMULA: WHEREIN : R1 IS HALO; R2 IS H OR HALO; R3 IS A) C1-C3 ALKYL, OPTIONALLY SUBSTITUTED BY HALO; OR B) -(CH2)N-MORPHOLINO, -(CH2)N-PIPERIDINE, -(CH2)N-PIPERAZINE, -(CH2)N-PIPERAZINE-N(C1-C3 ALKYL), -(CH2)N-PYRROLIDINE, OR -(CH2)N-IMIDAZOLE; N IS 1 TO 4; R4 IS -(CH2)M-HET; HET IS MORPHOLINE, PIPERIDINE, PIPERAZINE, PIPERAZINE-N(C1-C3 ALKYL), IMIDAZOLE, PYRROLIDINE, AZEPANE, 3,4-DIHYDRO-2H-PYRIDINE, OR 3,6-DIHYDRO-2H-PYRIDINE, EACH OPTIONALLY SUBSTITUTED BY ALKYL, HALO, OH, NH2, NH(C1-C3 ALKYL) OR N (C1-C3 ALKYL)2; M IS 1-3; AND X IS O, S OR NH; OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AS WELL AS PROCESSES AND INTERMEDIATE COMPOUNDS FOR MAKING THEM, USEFUL PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE COMPOUNDS IN THE TREATMENT OF PROLIFERATIVE DISEASES.