SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY

SUBSTITUTED AND PYRIDINES AND PYRIDAZINES HAVING ANGIOGENESIS INHIBITING ACTIVITY AND THE GENERALIZED STRUCTURAL FORMULA (FORMULA)WHEREIN THE RING CONTAINING A, B, D, E, AND L IS PHENYL OR A NITROGEN-CONTAINING HETEROCYCLE; GROUPS X AND Y MAY BE ANY OF A VARIETY OF DEFINED LINKING UNITS; R1 AND R2 M...

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Hauptverfasser:	ROBERT N. SIBLEY, JULIE A. DIXON, STEPHEN JAMES BOYER, TEDDY KITE JOE, NING SU, DANAPALAN NAGARATHNAM, HAROLD C.E. KLUENDER, JACQUES P. DUMAS, WENDY LEE
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	SUBSTITUTED AND PYRIDINES AND PYRIDAZINES HAVING ANGIOGENESIS INHIBITING ACTIVITY AND THE GENERALIZED STRUCTURAL FORMULA (FORMULA)WHEREIN THE RING CONTAINING A, B, D, E, AND L IS PHENYL OR A NITROGEN-CONTAINING HETEROCYCLE; GROUPS X AND Y MAY BE ANY OF A VARIETY OF DEFINED LINKING UNITS; R1 AND R2 MAY BE DEFINED INDEPENDENT SUBSTITUENTS OR TOGETHER MAY BE A RING-DEFINING BRIDGE; RING J MAY BE AN ARYL , PYRIDYL, OR CYCLOALKYL GROUP; AND G GROUPS MAY BE ANY OF A VARIETY OF DEFINED SUBSTITUENTS. PHARMACEUTICAL COMPOSITIONS CONTAINING THESE MATERIALS, AND METHODS OF TREATING A MAMMAL HAVING A CONDITION CHARACTERIZED BY ABNORMAL ANGIOGENESIS OR HYPERPERMIABILITY PROCESSES USING THESE MATERIALS ARE ALSO DISCLOSED.