4-MERCAPTOPYRROLIDINE DERIVATES A FARNESYL TRANSFERASE INHIBITORS

4-MERCAPTOPYRROLIDINE DERIVATES A FARNESYL TRANSFERASE INHIBITORS

PHARMACEUTICAL COMPOSITIONS COMPRISING AN INHIBITOR OF RAS FARNESYLATION OF FORMULA I WHEREIN: R1 IS FOR EXAMPLE H AND FURTHER VALUES AS DEFINED IN THE SPECIFICATION; R2 IS FOR EXAMPLE H AND FURTHER VALUES AS DEFINED IN THE SPECIFICATION; R3 IS FOR EXAMPLE H OR A SUBSTITUENT HAVING VALUES AS DEFINED...

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Hauptverfasser: PETER WEDDERBURN KENNY, DAVID HUW DAVIES, FRANCIS THOMAS BOYLE, ZBIGNIEW STANLEY MATUSIAK, JAMES MICHAEL WARDLEWORTH, PETER BEVERLEY SCHOLES
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:PHARMACEUTICAL COMPOSITIONS COMPRISING AN INHIBITOR OF RAS FARNESYLATION OF FORMULA I WHEREIN: R1 IS FOR EXAMPLE H AND FURTHER VALUES AS DEFINED IN THE SPECIFICATION; R2 IS FOR EXAMPLE H AND FURTHER VALUES AS DEFINED IN THE SPECIFICATION; R3 IS FOR EXAMPLE H OR A SUBSTITUENT HAVING VALUES AS DEFINED IN THE SPECIFICATION; P IS 0-3 IN WHICH R3 VALUES CAN BE THE SAME OR DIFFERENT; L IS A LINKING MOIETY FOR EXAMPLE -CO-NH2-AND FURTHER VALUES AS DEFINED IN THE SPECIFICATION; A IS SELECTED FROM PHENYL; NAPHTHYL; A 5-10 MEMBERED MONOCYCLIC OR BICYCLIC HETEROARYL RING CONTAINING UPTO 5 HETEROATOMS WHERE THE HETEROATOMS ARE INDEPENDENTLY SELECTED FROM O, N & S; OR A -S-S- DIMER THEREOF WHEN R2=H; OR AN ENANTIOMER, DIASTEREOISOMER, PHARMACEUTICALLY ACCEPTABLE SALT, PRODRUG OR SOLVATE USE IS CANCER THERAPY.