SUBSTITUTED BENZOPYRAN ANALOGS FOR THE TREATMENT OF INFLAMAMTION

A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' wherein X, A1, A2, A3, A4, R, R'', R1 and R2 are as de...

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Hauptverfasser:	STEPHEN R. BERTENSHAW, MARK G. OBUKOWICZ, DONALD J. ROGIER, JR, MATTHEW J. GRANETO, SUZANNE METZ, DONALD E. KORTE, DAVID L. BROWN, SUSAN J. HARTMANN, BALEKUDRU DEVADAS, CATHLEEN E. HANAU, JOHN J. TALLEY, SRINIVASAN R. NAGARAJAN, JEFFREY S. CARTER, CINDY LUDWIG
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' wherein X, A1, A2, A3, A4, R, R'', R1 and R2 are as described in the specification.