CYCLIC PEPTIDE ANTIFUNGAL AGENTS

PROVIDED ARE PHARMACEUTICAL FORMULATIONS, AND METHODS OF INHIBITING FUNGAL AND PARASITIC ACTIVITY USING A COMPOUND OF FORMULA I:(FORMULA 1)WHEREIN:R1 IS HYDROGEN, METHYL OR NH2C(O)CH2-; R''' AND R''' ARE INDEPENDENTLY METHYL OR HYDROGEN; RX1, RX2, RY1, RY2, RY3, AND RY4...

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Hauptverfasser:	MICHAEL JOHN RODRIGUEZ, VENKATRAGHAVAN (NMN) VASUDEVAN, PETER STANLEY BORROMEO, JAMES ANDREW JAMISON, WILLIAM WILSON TURNER, JUNIOR
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	PROVIDED ARE PHARMACEUTICAL FORMULATIONS, AND METHODS OF INHIBITING FUNGAL AND PARASITIC ACTIVITY USING A COMPOUND OF FORMULA I:(FORMULA 1)WHEREIN:R1 IS HYDROGEN, METHYL OR NH2C(O)CH2-; R''' AND R''' ARE INDEPENDENTLY METHYL OR HYDROGEN; RX1, RX2, RY1, RY2, RY3, AND RY4 ARE INDEPENDENTLY HYDROXY OR HYDROGEN;@R0 IS A GROUP OF THE FORMULA(FORMULA 2) R1 IS C1-C6 ALKYL, C1-C6 ALKOXY, PHENYL, P-HALO-PHENYL, P-NITROPHEYNL, PHENOXY, BENZYL, P-HALO-BENZYL, OR P-NITRO-BENZYL; ANDR2 IS AN ACYL SIDE CHAIN AS DEFINED HEREIN.