METHOD FOR THE RAPID SCREENING OF ANALYTES

A METHOD FOR THE RAPID SCREENING OF ANALYTES, SUCH AS PROTENTIAL DRUG CANDIDATES, COMPRISES THE STEPS OF APPLYING A PLURALITY OF ANALYTES TO BE SCREENED ONTO ONE OR MORE SOLID SUPPORT (S) (61) SUCH THAT THE ANALYTES REAMIN ISOLATED FROM ONE ANOTHER; CONTACTING SAID ANALYTE-CARRYING SOLID SUPPORT(S)...

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Hauptverfasser:	KOENRAAD LODEWIJK AUGUST VAN ACKER, RUDI WILFRIED JAN PAUWELS, CHRISTIAAN HUBERT SIMON ROELANT
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING TRANSPORTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A METHOD FOR THE RAPID SCREENING OF ANALYTES, SUCH AS PROTENTIAL DRUG CANDIDATES, COMPRISES THE STEPS OF APPLYING A PLURALITY OF ANALYTES TO BE SCREENED ONTO ONE OR MORE SOLID SUPPORT (S) (61) SUCH THAT THE ANALYTES REAMIN ISOLATED FROM ONE ANOTHER; CONTACTING SAID ANALYTE-CARRYING SOLID SUPPORT(S) (61) WITH TARGETS PROVIDED IN A SEMI-SOLID OR LIQUID MEDIUM, WHEREBY SAID ANALYTES ARE RELEASED FROM THE SOLID SUPPORT(S)(61) TO THE TARGETS; AND MEASURING ANALYTE-TARGET INTERACTIONS. THIS METHOD ALLOWS FOR THE MAINPULATION OF THOUSANDS OF DIFFERENT ANALYTES SIMULTANEOUSLY. WHEN THE ANALYTE IS APPLIED TO THE SOLID SUPPORT (61) IT CAN DIFFUSE THEREON SO AS TO PRODUCE A CONCENTRATION GRADIENT AND SERIAL DILUTION OF ANALYTE IF A DOSE RESPONSE CURVE FOR A CANDIDATE DRUG IS REQUIRED. THE METHOD DESCRIBED CAN BE READILY AUTOMATED.(FIG. 20)