RESPIRATORY SYNCYTIAL VIRUS REPLICATION INHIBITORS

THIS INVENTION CONCERNS THE COMPOUNDS OF FORMULA 1 PRODRUGS , N-OXIDES , ADDITION SALTS , QUATERNARY AMINES , METAL COMPLEXES OR STEREOCHEMICALLY ISOMERIC FORMS THEREOF WHEREIN -A1=A2-A3=A4-IS A RADICAL OF FORMULA -CH=CH-CH=CH-, -N =CH-CH=CH-,-CH=CH-N=CH-,-CH=CH-CH=N- WHEREIN EACH HYDROGEN ATOM MAY OPTIONALLY BE SUBSTITUTED; Q IS A RADICAL FORMULA WHEREIN ALK IS C1-6ALKANEDIYL; X1 IS NR4, S, S(=O), S(=O)2, O,CH2,C(=O), CH(=CH2), CH (OH), CH(CH3), CH(OCH3), CH(SCH3), CH(NR5AR5B), CH2-NR4 OR NR4-CH2; X2 IS A DIRECT BOND, CH2, C(=O) , NR4, C1-4ALKYL; T IS 2 TO 5; U IS 1 TO 5 ;V IS 2 OR 3; AND WHEREBY EACH HYDROGEN IN ALK AND IN (B-3) , (B-4), (B-5) , (B-6), (B-7) AND (B-8), MAY OPTIONALLY BE REPLACED BY R3; PROVIDED THAT WHEN R3; PROVIDED THAT WHEN R3 IS PROVIDED THAT WHEN R3 IS HYDROXY OR C1-6ALKYLOXY,THEN R3 CAN NOT REPLACE A HYDROGEN ATOM IN THE α POSITION RELATIVE TO A NITROGEN ATOM ; G IS SUBSTITUTED C1-10 ALKANEDIYL WHEREIN THE SUBSTITUENT IS ATTACHED VIA AN OXYGEN ATOM ; R1-6ALKYCARBONYL, PYRROLIDINYL, PIPERIDINYL, HOMOPIPERIDINYL, C3-7CYCLOALKYL OR C1-10ALKYL SUBSTITUTED WITH N(R6)2 AND OPTIONALLY WITH ANOTHER SUBSTITUENT ;R4 IS HYDROGEN , C1-6ALKYL OR ARYLC1-6ALKYL;R5A, R5B, R5C AND R5D ARE HYDROGEN OR C1-6ALKYL ;OR R5A AND R5B , OR R5C AND R5D TAKEN TOGETHER FROM A BIVALENT RADICAL OF FORMULA -(CH2)S-WHEREIN S IS 4 OR 5; R6 IS HYDROGEN , C1-4ALKYL , FORMYL, HYDROXYC1-6ALKYL, C1-6ALKYCARBONYL OR C1-6ALKYLOXYCARBONYL;ARYL IS OPTIONALLY SUBSTITUTED PHENYL ; HET IS PYRDYL, PYRIMIDINYL, PYRAZINYL, PYRIDAZINYL; AS RESPIRATORY SYNCYTIAL VIRYS REPLICATION INHIBITORS; THEIR PREPARATION , COMPOSITIONS CONTAINING THEM AND THEIR USE AS A MEDICINE .