1-(1,2-DISUBSTITUTED PIPERIDINYL)-4-(BENZIMIDAZOLYL-AND IMIDAZOPYRIDINYL)- PIPERIDINE DERIVATIVES

THIS INVENTION CONCERNS THE COMPOUNDS OF FORMULA(FORMULA 1) THE N-OXIDE FORMS, THE PHARMACEUTICALLY ACCEPTABLE ADDITION SALTS AND THE STEREOCHEMICALLY ISOMERIC FORMS THEREOF, WHEREIN N IS 0, 1 OR 2; M IS 1 OR 2, PROVIDED THAT IF M IS 2, THEN N IS 1; X IS A COVALENT BOND OR A BIVALENT RADICAL OF FORMULA -O-, -S-, -NR3-, =Q IS=O OR =NR3; R1 IS AR1, AR1C1-6ALKYL OR DI(AR1)C1-6ALKYL WHEREIN THE C1-6ALKYL GROUP IS OPTIONALLY SUBSTITUTED; R2 IS AR2, AR2C1-6ALKYL, HET OR HETC1-6ALKYL; L IS A BENZIMIDAZOLE OR IMIDAZOPYRIDINE DERIVATIVE OF FORMULA (A) OR (B) AR1 IS OPTIONALLY SUBSTITUTED PHENYL AR2 IS NAPHTALENYL OR OPTIONALLY SUBSTITUTED PHENYL; AND HET IS AN OPTIONALLY SUBSTITUTED MONOCYCLIC OR BICYCLIC HETEROCYCLE; AS SUBSTANCE P ANTAGONISTS; THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE AS A MEDICINE.