ANTHRANILIC ACID DERIVATIVES AS MULTI DRUG RESISTANCE MODULATORS

ANTHRANILIC ACID DERIVATIVES AS MULTI DRUG RESISTANCE MODULATORS

ANTHRANILIC ACID DERIVATIVES OF FORMULA (I):(FORMULA 1) WHEREIN EACH OF R TO R9 IS AN ORGANIC SUBSTITUENT, n IS 0 OR 1, m IS 0 OR AN INTEGER OF 1 TO 6, q IS 0 OR 1, X IS A DIRECT BOND, O, S, -S- (CH2)p- OR -O- (CH2)p- WHEREIN p IS FROM 1 TO 6 AND Ar IS AN UNSATURATED CARBOCYCLIC OR HETEROCYCLIC GROU...

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Hauptverfasser: SUSANNAH WILLIAMS, SUKHJIT HUNJAN, ADRIAN JOHN FOLKES, HAMISH RYDER, LEVI MICHAEL MAXIMEN, JASON TERRY SANDERSON, PHILIP ANTHONY ASHWORTH, MICHAEL ROE, JULIE ELIZABETH BRUMWELL
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:ANTHRANILIC ACID DERIVATIVES OF FORMULA (I):(FORMULA 1) WHEREIN EACH OF R TO R9 IS AN ORGANIC SUBSTITUENT, n IS 0 OR 1, m IS 0 OR AN INTEGER OF 1 TO 6, q IS 0 OR 1, X IS A DIRECT BOND, O, S, -S- (CH2)p- OR -O- (CH2)p- WHEREIN p IS FROM 1 TO 6 AND Ar IS AN UNSATURATED CARBOCYCLIC OR HETEROCYCLIC GROUP, AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, HAVE ACTIVITY AS INHIBITORS OF P-GLYCOPROTEIN AND MAY THUS BE USED, INTER ALIA, AS MODULATORS OF MULTIDRUG RESISTANCE IN THE TREATMENT OF MULTIDRUG RESISTANT CANCERS, FOR EXAMPLE TO POTENTIATE THE CYTOTOXICITY OF A CANCER DRUG.