FUSED IMIDAZOLE DERIVATIVES AS MULTIDRUG RESISTANCE MODULATORS

THIS INVENTION CONCERNS THE COMPOUNDS OF FORMULA (FORMULA 1) THE N-OXIDE FORMS, THE PHARMACEUTICALLY ACCEPTABLE ADDITION SALTS AND THE STEREOCHEMICALLY ISOMERIC FORMS THEREOF, WHEREIN THE DOTTED LINE IS AN OPTIONAL BOND; N IS 1 OR 2; R1 HYDROGEN; HALO; FORMYL; C1-4ALKYL OPTIONALLY SUBSTITUTED WITH HYDROXY, C1-4 ALKYLOXY, C1-4ALKYLCARBONYLOXY, IMIDAZOLYL, THIAZOLYL OR OXAZOLYL; OR A RADICAL OF FORMULA -X-COOR5, -X-CONR6R7 OR -X-COR10 WHEREIN -X- IS A DIRECT BOND, C1-4 ALKANEDIYL OR C2-6 ALKENEDIYL; R5 IS HYDROGEN, C1-12 ALKYL, AR, HET, C1-6 ALKYL SUBSTITUTED WITH C1-4ALKYLOXY, ARYL OR HETEROARYL; R6 AND R7 EACH INDEPENDENTLY ARE HYDROGEN OR C1-4ALKYL; R2 IS HYDROGEN, HALO, C1-4ALKYL, HYDROXYC1-4ALKYL, C1-4ALKYLOXYCARBONYL, CARBOXLY, FORMYL OR PHENYL; R3 IS HYDROGEN, C1-4ALKYL OR C1-4ALKYLOXY; R4 IS HYDROGEN, HALO, C1-4ALKYL, C1-4ALKYLOXY OR HALO C1-4ALKYL; Z IS -CH2-, -CH2-CH2-, -CH=CH-, -CHOH-CH2-, --O-CH2-, -C(=O)-CH2- OR -C(=NOH)-CH2-; -A-B- IS A BIVALENT RADICAL; A1 IS A DIRECT BOND, OPTIONALLY SUBSTITUTED C1-6ALKANEDIYL, C1-6ALKANEDIYL-OXY-C1-6ALKANEDIYL, CARBONYL, C1-6ALKANEDIYLCARBONYL, OPTIONALLY SUBSTITUTED C1-6ALKANEDIYLOXY; A2 IS A DIRECT BOND OR C1-6ALKANEDIYL;AND Q IS ARYL. PROCESSES FRO PREPARING SAID PRODUCTS, FORMULATIONS COMPRISING SAID PRODUCTS AND THEIR USE AS A MEDICINE ARE DISCLOSED, IN PARTICULAR FOR INHIBITING OR REVERSING THE EFFECTS OF MULTIDRUG RESISTANCE.