ANGIOGENESIS INHIBITING PYRIDAZINAMINES

THIS INVENTION CONCERNS COMPOUNDS OF FORMULA( FORMULA 1 )THE N-OXIDE FORMS, THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS AND STEREOCHEMICALLY ISOMERIC FORMS THEREOF, WHEREIN X IS CH OR N; M IS 2 OR 3 AND N IS 1, 2 OR 3; WHEREIN 1 OR 2 C-ATOMS OF THE CH2 GROUPS OF THE MOIETY, WHICH MAY ALSO CONTAIN ONE DOUBLE BOND, MAY BE SUBSTITUTED WITH C1-6ALKYL, AMINO, AMINOCARBONYL, MONO- OR DI(C1-6ALKYL)AMINO, C1-6ALKYLOXYCARBONY, C1-6ALKYL-CARBONYLAMINO, HYDROXY OR C1-6ALKYLOXY; AND/OR 2 C-ATOMS OF SAID CH2 GROUPS MAY BE BRIDGED WITH C2-4ALKANEDIYL; R1 IS HYDROGEN, C1-6ALKYL, C1-6ALKYLOXY. C1-6ALKYLTHIO, AMINO, MONO- OR DI(C1-6ALKYL)AMINO, AR, ARNH-, C3-6CYCLOALKYL, HYDROXYMETHYL OR BENZYLOXYMETHYL; R2 AND R3 ARE HYDROGEN, OR TAKEN TOGETHER MAY FORM A BIVALENT RADICAL OF FORMULA -CH=CH-CH=CH-; IN CASE X REPRESENT CH THEN L IS A RADICAL L1, L2 OR L3, OR IN CASE X REPRESENT N THEN L IS A RADICAL L2 OR L3; L1 IS AR-C1-6ALKYLOXY, AR-OXY, AR-THIO, AR-CARBONYLAMINO, DI-AR-METHYLOXY-, N-AR-PIPERAZINYL, N-AR-HOMOPIPERAZINYL, 2-BENZIMIDAZOLINONYL, AR-NR4-NR4-, AR-ALK-NR4-,AR-NR4-ALK-NR5- OR HET-NR4-; L2 IS AR, AR-CARBONYL, AR-CH=CH-CH2-, NAPHTALENYL OR HET; L3 IS C1-6ALKYL SUBSTITUTED WITH ONE OR TWO RADICALS SELECTED FROM AR, AR-OXY, OR AR-THIO, FURTHER OPTIONALLY SUBSTITUTED WITH CYANO OR HYDROXY; 2,2-DIMETHYL-1,2,3,4-TETRAHYDRO-NAPHTALENYL; 2,2-DIMETHYL-1H-2,3-DIHYDROINDENYL;AR-PIPERIDINYL OR AR-NR4-ALK-; R4 AND R5 ARE EACH INDEPENDENTLY SELECTED FROM HYDROGEN OR C1-6ALKYL; ALK IS C1-6ALKANEDIYL; THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE AS A MEDICINE.