NAPHTHYL COMPOUNDS, INTERMEDIATES, COMPOSITIONS, AND METHODS

THE PRESENT INVENTION PROVIDES PHARMACEUTICALLY ACTIVE COMPOUNDS FORMULA I@@(FORMULA I)@@WHEREIN@R1 IS -H, -OH, -O(C1-C4 ALKYL), -OCOC6H5, -OCO(C1-C6 ALKYL), OR -OSO2 (C2-C6 ALKYL);@@R2 IS -H, -OH, -O(C1-C4 ALKYL), -OCOC6H5, -OCO(C1-C6 ALKYL), -OSO2(C2-C6 ALKYL), OR HALO;@@R3 IS 1-PIPERIDINYL, 1-PYR...

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Bibliographische Detailangaben
1. Verfasser:	ALAN DAVID PALKOWITZ
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	THE PRESENT INVENTION PROVIDES PHARMACEUTICALLY ACTIVE COMPOUNDS FORMULA I@@(FORMULA I)@@WHEREIN@R1 IS -H, -OH, -O(C1-C4 ALKYL), -OCOC6H5, -OCO(C1-C6 ALKYL), OR -OSO2 (C2-C6 ALKYL);@@R2 IS -H, -OH, -O(C1-C4 ALKYL), -OCOC6H5, -OCO(C1-C6 ALKYL), -OSO2(C2-C6 ALKYL), OR HALO;@@R3 IS 1-PIPERIDINYL, 1-PYRROLIDINYL, METHYL-1-PYRROLIDINYL, DIMETHYL-1-PYRROLIDINO, 4-MORPHOLINO, DIMETHYLAMINO, DIETHYLAMINO, DIISOPROPYLAMINO, OR 1-HEXAMETHYLENEIMINO; AND@@N IS 2 OR 3; AND@OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF.@@ALSO PROVIDED ARE COMPOUNDS OF FORMULA II@@(FORMULA II)@@WHEREIN@R1A IS -H OR; -OR5 IN WHICH R5 IS A HYDROXY PROTECTING GROUP.@@R2A IS -H, HALO, OR -OR6 IN WHICH R6 IS A HYDROXY PROTECTING GROUP; AND@@R4 IS -OH OR -CHO;@OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF.@@FURTHER PROVIDED ARE PHARMACEUTICAL COMPOSITIONS OF COMPOUNDS OF FORMULA 1, AND METHODS OF USING FORMULA I COMPOUNDS FOR, INTER ALIA, ALLEVIATING THE SYMPTOMS OF POST MENOPAUSAL SYNDROME AND HORMONALLY-DEPENDENT CANCER, PARTICULARLY, BREAST CANCER.