ALLELIC VARIANTS OF PLASMODIUM FALCIPARUM MEROZOITE SURFACE ANTIGEN

ALLELIC VARIANTS OF PLASMODIUM FALCIPARUM MEROZOITE SURFACE ANTIGEN

A MEROZOITE SURFACE ANTIGEN OF PLASMODIUM FALCIPARUM SELECTED FROM THE CLASS CHARACTERISED BY:(I) HAVING A RELATIVE MOLECULAR MASS, MR, (DETERMINED BY SDS-POLYAERYLAMIDE GEL ELECTROPHORESIS)IN THE RANGE OF APPROXIMATELY 41,000 TO 53,000: AND (II) COMPRISING MULTIPLE ALLELIC FORMS OF MSA2, HAVING CON...

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Hauptverfasser: ALLAN JAMES SAUL, GRAHAM LLOYD JONES, DAVID OWEN IRVING, ROBIN FREDRIC ANDERS, DAVID JAMES KEMP, ROSS LEON COPPEL, SANDRA LEIGH DYER, JASON ARTHUR SMYTHE, DAVID WAI WING CHEE, NEIL HOWARD GOSS
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Zusammenfassung:A MEROZOITE SURFACE ANTIGEN OF PLASMODIUM FALCIPARUM SELECTED FROM THE CLASS CHARACTERISED BY:(I) HAVING A RELATIVE MOLECULAR MASS, MR, (DETERMINED BY SDS-POLYAERYLAMIDE GEL ELECTROPHORESIS)IN THE RANGE OF APPROXIMATELY 41,000 TO 53,000: AND (II) COMPRISING MULTIPLE ALLELIC FORMS OF MSA2, HAVING CONSERVED N-TERMINAL AND C-TERMINAL SEQUENCES:OR AN ANTIGENIC FRAGMENT THEREOF. PARTICULAR ANTIGENIC FRAGMENTS INCLUDE SEQUENCE CORRESPONDING TO REPEAT SEQUENCES AND SEQUENCES FROM CONSERVED N-TERMINAL AND C-TERMINAL REGIONS. PRODUCTION OF ANTIGENS BY RECOMBINANT DNA TECHNIQUES-AS FUSION AND NON-FUSION PROTEINS, AND USE IN VACCINE COMPOSITIONS IS ALSO DISCLOSED.