SUBSTITUTED ISOXAZOLE AND ISOTHIAZOLE DERIVATIVES

COMPOUNDS OF THE FORMULA WHEREIN A TOGETHER WITH THE TWO CARBON ATOMS DENOTED AS ? AND ? SIGNIFIES A GROUP OF THE FORMULA AND THE DOTTED LINE SIGNIFIES THE DOUBLE BOND PRESENT IN CASES (I) AND (III); AND WHEREIN N STANDS FOR ZERO, 1, 2 OR 3, ONE OF R1 AND R2 SIGNIFIES CARBOXY OR ALKOXYCARBONYL AND THE OTHER SIGNIFIES HYDROGEN, R3 SIGNIFIES HYDROGEN, ALKYL,ALKOXY, ARYLOXY, AZIDO, CYANO OR ALKYLTHIO, R4, R5, R6 AND R7 EACH SIGNIFY HYDROGEN OR ALKYL OR, WHEN R1 SIGNIFIES CARBOXY OR ALKOXYCARBONYL AND N STANDS FOR 1, R4 AND R6 TOGETHER CAN SIGNIFY A CARBON-CARBON BOND OR, WHEN R2 SIGNIFIES CARBOXY OR ALKOXYCARBONYL, R5 AND R7 TOGETHER CAN SIGNIFY A CARBON-CARBON BOND, R8 SIGNIFIES HALOGEN, ALKYL, HALOALKYL OR ALKOXY AND R9 SIGNIFIES HYDROGEN, HALOGEN, ALKYL OR ALKOXY, AND PHARMACEUTICALLY ACCEPTABLE SALTS OF THE COMPOUNDS OF FORMULA I IN WHICH ONE OF R1 AND R2 SIGNIFIES CARBOXY AND THE OTHER SIGNIFIES HYDROGEN WITH BASES, CAN BE USED AS MEDICAMENTS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS, INFLAMMATORY RESPIRATORY DISEASES, INFLAMMATORY BOWEL DISEASE, SHOCK AND INFLAMMATION ASSOCIATED WITH ISCHEMIA. THEY CAN BE MANUFACTURED ACCORDING TO GENERALLY KNOWN METHODS.