DAUNOMYCIN ANALOGUES

DAUNOMYCIN ANALOGUES

DAUNOMYCIN ANALOGUES OF THE FORMULA:(FORMULA 1)WHEREIN WHEN EACH R1 IS HYDROGEN, EACH R IS HYDROGEN, CHLORINE, BROMINE, METHYL OR METHOXY AND WHEN EACH R1 IS CHLORINE, BROMINE OR METHYL, EACH R IS HYDROGEN ARE USEFUL IN TREATING VARIOUS MAMMALIAN TUMORS AND ARE PREPARED BY REACTING A DAUNOMYCINONE D...

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Bibliographische Detailangaben
Hauptverfasser: BIANCA PATELLI, LUIGI BERNARDI, AURELIOMARCO, FEDERICO ARCAMONE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SUGARS
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Zusammenfassung:DAUNOMYCIN ANALOGUES OF THE FORMULA:(FORMULA 1)WHEREIN WHEN EACH R1 IS HYDROGEN, EACH R IS HYDROGEN, CHLORINE, BROMINE, METHYL OR METHOXY AND WHEN EACH R1 IS CHLORINE, BROMINE OR METHYL, EACH R IS HYDROGEN ARE USEFUL IN TREATING VARIOUS MAMMALIAN TUMORS AND ARE PREPARED BY REACTING A DAUNOMYCINONE DERIVATIVE OF THE FORMULA:(FORMULA 2)WHEREIN R AND R1 ARE AS DEFINED ABOVE WITH 1- CHLORO-2, 3, 6- TRIDEOXY- 3- TRIFLUOROACCTAMIDO- 4- TRIFLUOROACETOXY- (ALPHA)- L- LYXOPYRANOSE IN AN INERT ANHYDROUS ORGANIC SOLVENT IN THE PRESENCE OF A CATALYST AND A HYDROGEN CHLORIDE ACCEPTOR.