INDENE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF

The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer. Los derivados de indeno de la invencion de la formula (I) son capaces de modular selectivamente las actividades de receptores activados de peroxisomas proliferantes (PPARs), sin provocar efectos laterales adversos, y asi, son utiles para el tratamiento y prevencion de enfermedades moduladas por PPARs, es decir, sindromes metabolicos tales como diabetes, obesidad, arteriosclerosis, hiperlipidemia, hiperinsulinismo e hipertension, enfermedades inflamatorias tales como osteoporosis, cirrosis hepatico y asma, y cancer.