USE OF GENETIC POLYMORPHISMS THAT ASSOCIATE WITH EFFICACY OF TREATMENT OF INFLAMMATORY DISEASE

USE OF GENETIC POLYMORPHISMS THAT ASSOCIATE WITH EFFICACY OF TREATMENT OF INFLAMMATORY DISEASE

The MHC III region of chromosome 6p21.3 harbors a DNA sequence, most likely within the TNF or LTA gene, which influences response to pimecrolimus for the treatment of atopic dermatitis. Accordingly, genetic polymorphisms in the TNF andLTA genes are useful as biomarkers of the efficacy of pimecrolimu...

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Bibliographische Detailangaben
1. Verfasser: CHRISTIAN NICOLAS LAVEDAN
Format: Patent
Sprache:eng ; spa
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BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPIRITS
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Zusammenfassung:The MHC III region of chromosome 6p21.3 harbors a DNA sequence, most likely within the TNF or LTA gene, which influences response to pimecrolimus for the treatment of atopic dermatitis. Accordingly, genetic polymorphisms in the TNF andLTA genes are useful as biomarkers of the efficacy of pimecrolimus treatment of inflammatory disease. By contrast, response to tacrolimus appears to be influenced by other biological pathways. La region MHC III del cromosoma 6p21.3 aloja a una secuencia de ADN, mas posiblemente dentro del gen TNF o LTA, que tiene influencia sobre la respuesta al pimecrolimus para el tratamiento de dermatitis atopica. De acuerdo con lo anterior, los polimorfismos geneticos en los genes TNF y LTA son utiles como biomarcadores de la eficacia del tratamiento con pimecrolimus de la enfermedad inflamatoria. En contraste, la respuesta al tacrolimus parece ser influenciada por otras sendas biologicas.