PROCESSES FOR THE PREPARATION OF N-((((PYRIDINYLOXY) -PHENYLAMINO) QUINAZOLINYL)- ALLYL) ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS WELL AS INTERMEDIATES OF SUCH PROCESSES AND PROCESSES FOR THE PREPARATION OF SUCH INTERMEDIATES

The invention relates to processes for preparing compounds of the formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R3, R4, R6 R11, R13 R14 R15, R16, R17, k, I, and m are as defined herein. The present invention also relates to intermediates represented by the formula (3a) wherin R4, and R5 are independently selected from hydrogen and C1-C6alkyl; each R13, R14, R15 and R16 is independently selected from hydrogen, C1-C6alkyl and CH2OH, R17 and R18 are independently C1-C6 alkyl, and k and I are independently an integer from 1 to 3, as well as to a process for preparing these intermediates. La invencion se refiere a procedimientos para preparar compuestos de formula 1 (ver formula 1) y a sus sales, profarmacos y disolventes farmaceuticamente aceptables, en la que R1, R3, R4, R6, R11, R13, R14, R15, R16, R17, k, l y m son como se han definido en la presente memoria; los compuestos de formula 1 son productos intermedios utiles para preparar compuestos que se pueden usar en el tratamiento del crecimiento celular anormal en mamiferos, administrando composiciones farmaceuticas.