PYRAZOLE COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES

The present invention relates to pharmaceutical compositions comprising compounds of the Formula (I), and methods of selectively inhibiting or antagonizing the alphaVbeta3 and/or the alpha Vbeta5 integrin without significantly inhibiting the alpha Vbeta6 integrin. La presente invencion proporciona v...

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Bibliographische Detailangaben
1. Verfasser:	HUFF, RENEE M
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to pharmaceutical compositions comprising compounds of the Formula (I), and methods of selectively inhibiting or antagonizing the alphaVbeta3 and/or the alpha Vbeta5 integrin without significantly inhibiting the alpha Vbeta6 integrin. La presente invencion proporciona variantes de clanovirina-N y polimeros solubles en agua, en particular conjugados pegilados de los mismos. La clanovirina-N de la invencion esta particularmente adaptada para fijacion covalente selectiva puntual de uno o mas polimeros solubles en agua, para proporcionar conjugados polimericos de variantesde clanovirina-N que exhiben actividad anti-viral.