SOLID DISPERSIONS COMPRISING A HYGROSCOPIC AND/OR DELIQUESCENT DRUG

A pharmaceutical composition is provided, comprising a solid dispersion having a carrier medium that comprises (a) a matrix forming agent selected from hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose phthalate, polyvinyl pyrrolidone, polyethylene glycol, polyglycolized glycerides, cyclodextrins and carbomers, and (b) a filler, and having a hygroscopic and/or deliquescent drug dispersed or dissolved in the carrier medium. The composition is acceptably non-hygroscopic. Se proporciona una composicion farmaceutica, que comprende una dispersion que tiene un medio portador que comprende (a) un agente formador de matriz seleccionado de hidroxietilcelulosa, hidroxipropilcelulosa, hidroxipropilmetilcelulosa, hidroxipropilmetilcelulosa ftalato, polivinyl pirrolidona, polietileno glicol, gliceridos poliglicolizados, ciclodextrinas y carbomeros y (b) y un cargador que tiene un farmaco higroscopico y/o delicuescente disperso o disuelto en el medio portador. La composicion es aceptable no higroscopica.