SUBSTITUTED INDOLEPYRIDINIUM AS ANTI-INFECTIVE COMPOUNDS

The present invention concerns the compounds of formula (1) (R3)n P(I) N O R1 R2 their N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites, wherein n is 1, 2 or 3; R1 is H, CN, halo, aminoC(=O), C(=O)OH, C1-4-alkyloxyC(=O), C1-4alkylC(='O), mono- or di(C1-4alkyl)aminoC(=O), arylaminoC(=O), N-(aryl)-N-(C1-4alkyl)aminoC(=O), methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het1 or Het2; R2 is H, C1-10alkyl, C2-10allkenyl, C3-7cycloalkyl, wherein said C1-10alkyl,C2-10alkenyl and C3-7cycloalkyl may be optionally substituted; R3 is nitro, cyano, amino, halo, hydroxy,C1-4alkyloxy, hydroxyC(=O), aminoC(=O), C1-4alkyloxyC(=O), mono- or di(C1-4-alkyl)aminoC(=O), C1-4alkylC(=O), methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, N-hydroxy methanimidamidyl or Het1; for use as a medicine. The invention further relates to a novel subgroup of the compounds of formula (I), and to compositions comprising compounds of formula (I). La presente invencion se refiere a los compuestos de la formula (I) (ver formula (I)) sus N-oxidos, sales, formas estereoisomericas, mezclas racemicas, profarmacos, esteres y metabolitos, en la cual n es 1, 2, o 3; R1 es H, CN, halo, amino C(=O), C(=O)OH, alquiloxi C1-4C(=O), alquil C1-4C(=O), mono- o di(alquil C1-4aminoC(=O), arilaminoC(=O), N-(aril)-N-(alquil C1-4)aminoC(=O), metanimidamidilo, N-hidroxi-metanimidamidilo, mono- o di(alquil C1-4)metanimidamidilo, Het1 o Het2; R2 es H, alquilo C1-10, alquenilo C2-10, cicloalquilo C3-7, en donde dicho alquilo C1-10, alquenilo C2-10 y cicloalquilo C3-7 pueden estar opcionalmente sustituidos; R3 es nitro, ciano, amino, halo, hidroxi, alquiloxi C1-4, hidroxi C(=O), amino C(=O), alquiloxi C1-4C(=O), mono- o di(alquil C1-4)amino C(=O), alquil C1-4 C(=O, metanimidamidilo, mono- o di(alquil C1-4)metanimidamidilo, N-hidroxi-metanimidamidilo o Het1; para usar como medicamento; la invencion tambien se refiere a un nuevo subgrupo de compuestos de la formula (I) y a composiciones que comprende los compuestos de la formula (I).