8-AZAPROSTAGLANDIN DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT

8-Azaprostaglandin represented by the following general formula (I), pharmacologically acceptable salts thereof or cyclodextrin clathrates of the same: (I) wherein each symbol is as defined in the description. Because of strongly binding to PGE receptor subtype EP2, the compounds represented by the...

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1. Verfasser: TSUTOMU SHIROYA
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Sprache:eng ; spa
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Zusammenfassung:8-Azaprostaglandin represented by the following general formula (I), pharmacologically acceptable salts thereof or cyclodextrin clathrates of the same: (I) wherein each symbol is as defined in the description. Because of strongly binding to PGE receptor subtype EP2, the compounds represented by the general formula (I) are useful in preventing and/or treating immune diseases, allergic diseases, nerve cell death, paramenia, premature birth, misbirth, baldness, retinal neuropathy such as glaucoma, erectile dysfunction, arthritis, pulmonary injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, hepatic injury, acute hepatitis, cirrhosis, shock, nephritis, renal insufficiency, circulatory diseases, systemic inflammatory response syndrome, sepsis, hemophagous syndrome, macrophage activation syndrome, StillaC¦s disease, Kawasaki disease, burn, systemic granuloma, ulcerative colitis, CrohnaC¦s disease, hypercytokinemia at dialysis, multiorgan failure, bone diseases and so on. La presente invencion se refiere a 8-azaprostagladina representada por la siguiente formula general (I), sales farmacologicamente aceptables de la misma o clatratos de ciclodextrina de la misma: (I) en donde cada simbolo es como se definio en la descripcion. Debido al fuerte enlace al receptor de PGE subtipo EP2, los compuestos representados por la formula general (I) son utiles en la prevencion y/o tratamiento de enfermedades inmunes, enfermedades alergicas, muerte de celulas nerviosas, paramenia, nacimiento prematuro, aborto, calvicie, neuropatia retinal tal como glaucoma, disfuncion erectil, artritis, lesion pulmonar, fibrosis pulmonar, enfisema pulmonar, bronquitis, enfermedad pulmonar obstructiva cronica, lesion hepatica, hepatitis aguda, cirrosis, apoplejia nefritis, insuficiencia renal, enfermedades circulatorias, sindrome de respuesta inflamatoria sistemica, sepsis, sindrome de hemofagos, sindrome de activacion de macrofagos, enfermedad de still, enfermedad de Kawasaki, quemadura, granuloma sistemico, colitis ulcerativa, enfermedad de Crohn, hipercitocinemia en dialisis, falla de organo multiple, enfermedades de los huesos y asi sucesivamente.