DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS

Benzimidazole derivatives of formula (I) , which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases. (I). Los d...

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1. Verfasser:	MARCUS SEMONES
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Benzimidazole derivatives of formula (I) , which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases. (I). Los derivados de bencimidazola de la formula (I), que son utiles como inhibidores de TIE-2 y/o VEGFR-2 se describen en la presente. La invencion descrita tambien incluye metodos para hacer tales derivados de bencimidazola asi como tambien metodos para utilizar los mismos en el tratamiento de enfermedades hiperproliferativas.