PYRIMIDINE DERIVATIVES AS RHO-KINASE INHIBITORS

Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease. Derivados de pirimidin...

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1. Verfasser:	HOLIA, HATOUM-MOKDAD
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease. Derivados de pirimidina como inhibidores de rho-quinasa(Ver formula I)La invencion se refiere a compuestos derivados de los mismos, su sintesis, y sus usos como inhibidores de Rho-Quinasa. Estos compuestos son utiles para inhibir el crecimiento de tumores, tratamiento en la disfuncion erectil, y tratamiento de otras indicaciones reguladoras para Rho-Quinasa, es decir, para enfermedades coronarias y del corazon.