AFFINITY-ASSAY FOR THE HUMAN ERG POTASSIUM CHANNEL

The invention relates to an assay to establish the affinity of compounds at the "ether-a-go-go" (ERG) potassium (K+) channel, in particular the human ERG (hERG) potassium channel, using a labelled inwardly rectifying potassium channel (IKR) blocker. This assay is useful to identify compoun...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser:	PAMELA MAY GREENGRASS
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The invention relates to an assay to establish the affinity of compounds at the "ether-a-go-go" (ERG) potassium (K+) channel, in particular the human ERG (hERG) potassium channel, using a labelled inwardly rectifying potassium channel (IKR) blocker. This assay is useful to identify compounds with undesirable effects on cardiac repolarisation in man, in particular the propensity to prolong the QT interval in the electrocardiogram. La invencion se refiere a una prueba para establecer la afinidad de compuestos en el canal de potasio (K+) de "eter-a-go-go" (ERG), en particular el canal de potasio de ERG humano (hERG), utilizando un bloqueador de canal de potasio de rectificacion interna marcado (IKR); esta prueba es util para identificar compuestos con efectos no deseables en repolarizacion cardiaca en el hombre, en particular la propension a prolongar el intervalo de QT en el electrocardiograma.