PYRIDINE MATRIX METALLOPROTEINASE INHIBITORS

Selective MMP-13 inhibitors are pyridine derivatives of the formula (I) or a pharmaceutically acceptable salt thereof, wherein: R1 and R2 independently are hydrogen, halo, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, NO2, NR4R5, CN, or CF3; E is independently O or S; A and B independently are OR4 or NR4R5; R4 and R5 independently are H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)n aryl, (CH2)n cycloalkyl, (CH2)n heteroaryl, or R4 and R5 when taken together with the nitrogen to which they are attached complete a 3- to 8-membered ring containing carbon atoms and optionally containing a heteroatom selected from O, S, or NH, and optionally substituted or unsubstituted; n is 0 to 6. Inhibidores selectivos de MMP-13 son derivados de piridina de la formula (Ver formula) o una sal farmaceuticamente aceptable del mismo, en donde: R1 y R2, independientemente, son hidrogeno, halo, hidroxi, alquilo C1-C6, alcoxi C1-C6, alquenilo C2,-C6, alquinilo C2-C6, NO2, NR4R5, CN O CF3; E es, independientemente, O o S ; A y B, independientemente, son OR4 o NR4R5; R4 y R5,independientemente, son H, alquilo C1-C6, alquenilo C2-C6, alquinilo C2-C6, (CH2),arilo, (CH2)n ,cicloalquilo, (CH,)n heteroarilo, o R4 y R5, cuando se toman junto con el nitrogeno al que estan unidos, completan un anillo de 3 a 8 miembros que contiene atomos de carbono y que contiene, opcionalmente, un heteroatomo seleccionado de O, S o NH, y que, opcionalmente, esta sustituido o no sustituido; n es un numero entero de 0 a 6.