NEW MACROLIDES WITH ANTIBACTERIAL ACTIVITY

The invention provides new macrolides antibiotics of formula (I) with improved biological properties and improved stability formula (I): wherein R is hydrogen, cyano, -S(L)mR , -S(O)(L)mR , or -S(O)2(L)mR ; L represents -(CH2)n- or -(CH2)nZ(CH2)n'--; m is 0 or 1; n is 1, 2, 3, or 4; n' is...

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1. Verfasser:	ANGEHRN, PETER
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	The invention provides new macrolides antibiotics of formula (I) with improved biological properties and improved stability formula (I): wherein R is hydrogen, cyano, -S(L)mR , -S(O)(L)mR , or -S(O)2(L)mR ; L represents -(CH2)n- or -(CH2)nZ(CH2)n'--; m is 0 or 1; n is 1, 2, 3, or 4; n' is 0, 1, 2, 3, or 4; Z is O, S or NH; R2 is hydrogen, alkyl, heterocyclyl or aryl; which heterocyclyl and the aryl groups may be further substituted; * indicates a chiral center which is in the (R) or (S) form and pharmaceutically acceptable acid addition salts or in vivo cleavable esters thereof.