A GLYCOPEPTIDE AND PREPARATION THEREOF

The stereospecific synthesis of a glycopeptide using a triply orthogonal protection scheme is described, in particular, the synthesis of N-acetylglucosaminyl-bgr;-(1, 4)-N-acetylmuramylmonopeptide and derivatives thereof. The glycopeptide is useful for the preparation of N-acetylglulosaminyl-N-acety...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
1. Verfasser:	VANNIEUWENHZE, MICHAEL, SCOTT
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SUGARS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The stereospecific synthesis of a glycopeptide using a triply orthogonal protection scheme is described, in particular, the synthesis of N-acetylglucosaminyl-bgr;-(1, 4)-N-acetylmuramylmonopeptide and derivatives thereof. The glycopeptide is useful for the preparation of N-acetylglulosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutamine and related compounds having a glucosaminyl-bgr;-(1,4)-N-acetylmuramic acid disaccharide core. Se describe la sintesis estereoespecifica de un glucopeptido utilizando un esquema de proteccion ortogonal triple, en particular, la sintesis de N-acetilglucosaminil -(- [1,4] -N-acetilmuramilmonopeptido y derivados del mismo. El glucopeptido es util para la preparacion de GMDP y compuestos relacionados que tienen un nucleo disacarido de acido glucosaminil -(- [1,4( -N-acetilmuramico.