APLIDINE TREATMENT OF CANCERS

Aplidine demonstrates considerable promise in phase (I) clinical trials for treatment of tumours, and various dosing regimes are given. Tumor reduction has been observed in several tumour types including renal carcinoma, colorectal cancer, lung carcinoid, medullary thyroid carcinomas and melanoma. It has also been found that aplidine has a role in inhibiting angiogenesis, complementing the anti tumour activity. Aplidina demuestra promesa considerable en pruebas clinicas de fase (1) para el tratamiento de tumores, y varios regimenes de dosificacion se dan. La reduccion de tumor se ha observado en varios tipos de tumor incluyendo carcinoma renal, cancer colorectal, carcinoide pulmonar; carcinomas de tiroides medular y melanoma. Tambien se ha encontrado que aplidina tiene un papel, para inhibir angiogenesis, complementado la actividad anti-tumor.